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KMID : 0356619960110020240
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Journal of Korean Society of Endocrinology
1996 Volume.11 No. 2 p.240 ~ p.246
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Two cases of hypoglycemia in IDDM and NIDDM patients with insulin antibody
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김경아
이관우/김미림/장재남/김여주/배성권/손병관
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Abstract
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Hirata et al, first described the association of insulin antibodies with hypoglycemia attacks and decreased glucose tolerance in a patient who had not previously received insulin injections. Since that time there have been additional reports in
the
Japanese literature, Insulin antibodies are present in most of the patients who received insulin for a period of time, usually exceeding six weeks. There were several reports of hypoglycemia in patients with non-insulin-dependent diabetes
mellitus
who
had developed insulin antibody after insulin administration and also in patients with insulin dependent diabetes mellitus. It is well known that either insulin antibody to the lower affinity site or insulin receptor antibody can be a cause of
hypoglycemia. Recently, we experienced two cases of hypoglycemia in patient with insulin dependent diabetes mellitus and non- insulin- dependent diabetes mellitus who had developed insulin antibody after insulin administration. Hereby we present
these
cases with review of the literature(J Kor Soc Endocrinol 11 : 240~246, 1996).
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KEYWORD
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